I-molecule ye-Hyaluronic acid (HA) iqukethe inani elikhulu lamaqembu e-hydroxyl kanye namanye amaqembu e-polar, angamunca amanzi cishe izikhathi eziyi-1000 isisindo sawo njengesiponji “se-molecular”. Idatha ikhombisa ukuthi i-HA inokumunca komswakama okuphezulu ngaphansi komswakama ophansi (33%), kanye nokumunca komswakama okuphansi ngaphansi komswakama ophezulu (75%). Lesi sici esiyingqayizivele sivumelana nezidingo zesikhumba ezinkathini ezahlukene kanye nasezindaweni ezahlukene zomswakama, ngakho-ke saziwa njengesici semvelo esifanelekile sokumunca umswakama. Eminyakeni yamuva nje, ngokuthuthukiswa kobuchwepheshe bokukhiqiza kanye nokuthandwa kwezicelo zokunakekelwa kwesikhumba ze-HA, ezinye izinkampani ezintsha ziqale ukuhlola izindlela zokulungiselela izindwangu ze-HA.

Ukupheda

Indlela yokugoqa iyindlela yokucubungula esebenzisa i-ejenti yokuqeda equkethe i-HA ukwelapha indwangu ngokugoqa. Izinyathelo ezithile ukucwilisa indwangu esixazululweni sokuqeda isikhathi esithile bese uyikhipha, bese uyidlulisa ekucindezelweni nasekuwomiseni ukuze ekugcineni kulungiswe i-HA endwanguni. Izifundo zikhombisile ukuthi ukwengeza i-HA enqubweni yokuqeda izindwangu ezilukiwe ze-nylon warp akunamthelela omkhulu embaleni nasekuqineni kombala kwendwangu, futhi indwangu ephathwe nge-HA inomphumela othile wokufumisa. Uma indwangu elukiwe icutshungulwa ibe yi-fiber linear density engaphansi kuka-0.13 dtex, amandla okubopha e-HA ne-fiber angathuthukiswa, futhi ikhono lokugcina umswakama lendwangu lingagwenywa ngenxa yokuwasha nezinye izici. Ngaphezu kwalokho, amalungelo obunikazi amaningi abonisa ukuthi indlela yokugoqa ingasetshenziswa futhi ekuqedeni ukotini, usilika, i-nylon/spandex blends nezinye izindwangu. Ukwengezwa kwe-HA kwenza indwangu ithambe futhi ikhululeke, futhi inomsebenzi wokufumisa nokunakekela isikhumba.

Ukufakwa kwe-Microcapsulation

Indlela ye-microcapsule iyindlela yokugoqa i-HA kuma-microcapsules ngezinto ezakha ifilimu, bese kulungiswa ama-microcapsules kuma-fiber endwangu. Uma indwangu ithintana nesikhumba, ama-microcapsules ayaqhuma ngemva kokungqubuzana nokucindezela, bese ekhulula i-HA, futhi inomthelela wokunakekelwa kwesikhumba. I-HA iyinto encibilikayo emanzini, ezolahleka kakhulu ngesikhathi senqubo yokuwasha. Ukwelashwa nge-microencapsulation kuzokwandisa kakhulu ukugcinwa kwe-HA endwangu futhi kuthuthukise ukuqina kokusebenza kwendwangu. I-Beijing Jiershuang High-Tech Co., Ltd. yenza i-HA yaba ama-nano-microcapsules futhi yawasebenzisa ezindwangu, futhi izinga lokubuyiselwa komswakama kwezindwangu lafinyelela ngaphezu kuka-16%. U-Wu Xiuying walungisa i-microcapsule emanzi equkethe i-HA, wayibeka ku-polyester encane kanye nezindwangu zikakotini ezihlanzekile ngokusebenzisa i-resin exhumanisayo esezingeni lokushisa eliphansi kanye nobuchwepheshe bokulungisa izinga lokushisa eliphansi ukuze kutholakale ukugcinwa komswakama okuhlala isikhathi eside kwendwangu.

Indlela yokumboza

Indlela yokumboza ibhekisela endleleni yokwenza ifilimu equkethe i-HA ebusweni bendwangu, kanye nokufeza umphumela wokunakekelwa kwesikhumba ngokuxhumana ngokuphelele nendwangu nesikhumba ngesikhathi senqubo yokugqokwa. Isibonelo, ubuchwepheshe bokuzihlanganisa nge-electrostatic self-assembly bezendlalelo ngezendlalelo busetshenziselwa ukufaka ngokushintshana uhlelo lokuhlanganisa i-chitosan cation kanye nohlelo lokuhlanganisa i-anion lwe-HA ebusweni bezintambo zendwangu kakotini. Le ndlela ilula kakhulu, kodwa umphumela wendwangu yokunakekela isikhumba elungisiwe ungase ulahleke ngemva kokuwashwa kaningi.

Indlela yefayibha

Indlela yefayibha iyindlela yokwengeza i-HA esigabeni se-fiber polymerization noma i-dope yokuphotha, bese iphotha. Le ndlela yenza i-HA ingabi khona nje kuphela ebusweni befayibha, kodwa futhi isatshalaliswe ngokulinganayo ngaphakathi kwefayibha, ngokuqina okuhle. UMILAŠIUS R nabanye basebenzise ubuchwepheshe be-electrospinning ukusabalalisa i-HA ngesimo samaconsi kuma-nanofiber. Ukuhlolwa kubonise ukuthi i-HA ihlala ngisho nangemva kokucwiliswa emanzini ashisayo angu-95 ℃. I-HA iyisakhiwo se-polymer eside, futhi indawo yokusabela enobudlova ngesikhathi senqubo yokuphotha ingabangela umonakalo esakhiweni sayo sama-molecule. Ngakho-ke, abanye abacwaningi baye balungisa i-HA kusengaphambili ukuze bayivikele, njengokulungiselela i-HA negolide kuma-nanoparticles, bese beyihlakaza ngokulinganayo. Phakathi kwemicu ye-polyamide, imicu yendwangu yobuhle enokuqina okuphezulu nokusebenza kahle ingatholakala.