I-molecule ye-Hyaluronic acid (HA) iqukethe inani elikhulu lamaqembu e-hydroxyl namanye amaqembu asezindaweni ezishisayo, angakwazi ukumunca amanzi cishe izikhathi eziyi-1000 kwesisindo sawo "njengesipontshi se-molecular". Idatha ibonisa ukuthi i-HA inokumunca umswakama ophezulu uma kuqhathaniswa nomswakamo ophansi ohlobene (33%), kanye nokumunca umswakama ophansi ngaphansi komswakama ophezulu ohlobene (75%). Lesi sakhiwo esiyingqayizivele sivumelana nezidingo zesikhumba ezinkathini ezahlukene zonyaka kanye nezindawo ezihlukene zomswakama, ngakho-ke saziwa njengento efanelekile yokuthambisa yemvelo. Eminyakeni yamuva nje, ngokuthuthukiswa kobuchwepheshe bokukhiqiza kanye nokuthandwa kwezicelo zokunakekelwa kwesikhumba ze-HA, ezinye izinkampani ezintsha seziqalile ukuhlola izindlela zokulungiselela izindwangu ze-HA.

Ukupheqa

Indlela ye-padding iyindlela yokucubungula esebenzisa i-ejenti yokuqedela equkethe i-HA ukuze iphathe indwangu nge-padding. Izinyathelo eziqondile ukucwilisa indwangu kwisisombululo sokuqeda isikhathi esithile bese uyikhipha, bese uyidlulisa ngokucindezela nokomisa ukuze ekugcineni ulungise i-HA kwendwangu. Ucwaningo luye lwabonisa ukuthi ukwengeza i-HA ekuqedeni izindwangu ezilukiwe ze-nylon warp kunomphumela omncane kumbala nokushesha kombala kwendwangu, futhi indwangu ephathwa nge-HA inomphumela othile wokuthambisa. Uma indwangu elukiwe icutshungulwa ku-fiber linear density engaphansi kuka-0.13 dtex, amandla okubopha we-HA ne-fiber angathuthukiswa, futhi amandla okugcina umswakama wendwangu angagwenywa ngenxa yokuwashwa nezinye izici. Ngaphezu kwalokho, amalungelo obunikazi amaningi abonisa ukuthi indlela yokunamathisela ingasetshenziswa futhi ekuqedeni ukotini, usilika, imixube yenylon/spandex nezinye izindwangu. Ukwengezwa kwe-HA kwenza indwangu ithambile futhi ikhululekile, futhi inomsebenzi wokuthambisa nokunakekelwa kwesikhumba.

I-Microencapsulation

Indlela ye-microcapsule iyindlela yokugoqa i-HA kuma-microcapsules ngezinto zokwakha ifilimu, bese ulungisa ama-microcapsules emicu yendwangu. Lapho indwangu ithintana nesikhumba, ama-microcapsules aqhuma ngemva kokungqubuzana nokukhama, futhi akhulule i-HA, enza umphumela wokunakekelwa kwesikhumba. I-HA iyinto encibilikayo emanzini, ezolahleka kakhulu ngesikhathi sokugeza. Ukwelashwa kwe-microencapsulation kuzokwandisa kakhulu ukugcinwa kwe-HA kwendwangu futhi kuthuthukise ukuqina kokusebenza kwendwangu. I-Beijing Jiershuang High-Tech Co., Ltd. yenza i-HA ibe ama-nano-microcapsules yawafaka ezindwangu, futhi izinga lokubuyisela umswakama wezindwangu lifinyelele ngaphezu kuka-16%. U-Wu Xiuying ulungise i-microcapsule eswakamisayo equkethe i-HA, wayigxilisa ku-polyester emincane nezindwangu zikakotini ezihlanzekile ngokusebenzisa i-resin ehlanganisa izinga lokushisa eliphansi kanye nobuchwepheshe bokulungisa obusezingeni eliphansi ukuze kutholakale ukugcinwa komswakama okuhlala isikhathi eside kwendwangu.

Indlela yokugqoka

Indlela yokugcoba ibhekisela endleleni yokwenza ifilimu ene-HA ebusweni bendwangu, nokufeza umphumela wokunakekelwa kwesikhumba ngokuthintana ngokugcwele nendwangu ngesikhumba ngesikhathi sokugqoka. Isibonelo, ubuchwepheshe bokuzenzela be-electrostatic self-assembly obungqimba nge-layer busetshenziselwa ukufaka ngokuhlukile uhlelo lokuhlanganisa i-chitosan cation kanye nesistimu yokuhlanganisa ye-HA anion ebusweni bemicu yendwangu kakotini. Le ndlela ilula, kodwa umphumela wendwangu yokunakekelwa kwesikhumba elungiselelwe ungase ulahleke ngemva kokugeza okuningi.

Indlela ye-Fiber

Indlela yefayibha iyindlela yokwengeza i-HA esigabeni se-fiber polymerization noma i-spinning dope, bese iyaphotha. Le ndlela yenza i-HA ingabi khona kuphela ebusweni be-fiber, kodwa futhi isatshalaliswe ngokulinganayo ngaphakathi kwefayibha, ngokuqina okuhle. MILAŠIUS R et al. wasebenzisa ubuchwepheshe be-electrospinning ukusabalalisa i-HA ngendlela yamaconsi kuma-nanofibers. Ukuhlola kubonise ukuthi i-HA ihlala ngisho nangemva kokucwiliswa emanzini ashisayo angama-95 ℃. I-HA iyisakhiwo se-polymer eside, futhi indawo yokusabela enodlame phakathi nenqubo yokuphotha ingase ibangele umonakalo esakhiweni sayo samangqamuzana. Ngakho-ke, abanye abacwaningi baye benza ngaphambili i-HA ukuze bayivikele, njengokulungiselela i-HA negolide kuma-nanoparticles, bese bewahlakaza ngokulinganayo Phakathi kwemicu ye-polyamide, imicu yezindwangu yezimonyo enokuqina okuphezulu nokusebenza kahle ingatholakala.